Technologies for preserving kidney function in patients with chronic kidney disease and hyperuricemia
DOI:
https://doi.org/10.22141/2307-1257.10.1.2021.227201Keywords:
chronic kidney disease, hyperuricemia, renal replacement therapyAbstract
The prevalence of chronic kidney disease (CKD) and hyperuricemia is increasing globally. The steady increase in the number of patients with impaired renal function associated with diabetes mellitus, arterial hypertension, and an increase in life expectancy ultimately leads to significant costs associated with the need to use expensive methods of renal replacement therapy. The main task for physicians is the timely determination and slowing down of the progression of CKD, and renoprotection. Hyperuricemia is considered an independent risk factor for the onset and progression of the disease, in addition to the traditional microalbuminuria and decreased glomerular filtration rate. The urgency of detecting hyperuricemia is due to the possibility of its further correction to improve the prognosis of the disease and delay the end stage of CKD, improve the quality of life and reduce the cost of treatment of patients. A decrease in the total pool of uric acid in the body helps to minimize the risk of arthropathy and nephrolithiasis, exacerbation of gout, progression of renal failure and other complications. However, despite hundreds of published clinical studies on the diagnosis and treatment of patients with CKD, the quality of care remains suboptimal. The article presents versatile technologies of preserving renal function in patients with CKD and hyperuricemia, which require improvement.
Downloads
References
Mount DB. Hypouricemia: сauses and clinical significance. Available from: https://www.uptodate.com/contents/hypouricemia-causes-and-clinical-significance. Accessed: September 14, 2020.
Balakumar P, Maung-U K, Jagadeesh G. Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol Res. 2016 Nov;113(Pt A):600-609. doi:10.1016/j.phrs.2016.09.040.
Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011 Dec;80(12):1258-1270. doi:10.1038/ki.2011.368.
Neuen BL, Chadban SJ, Demaio AR, Johnson DW, Perkovic V. Chronic kidney disease and the global NCDs agenda. BMJ Glob Health. 2017 Jul 6;2(2):e000380. doi:10.1136/bmjgh-2017-000380.
National Collaborating Centre for Chronic Conditions (UK). Chronic Kidney Disease: National Clinical Guideline for Early Identification and Management in Adults in Primary and Secondary Care. London: Royal College of Physicians (UK); 2008. 237 p.
Rifkin DE, Shlipak MG, Katz R, et al. Rapid kidney function decline and mortality risk in older adults. Arch Intern Med. 2008 Nov 10;168(20):2212-2218. doi:10.1001/archinte.168.20.2212.
Sharaf El Din UA, Salem MM, Abdulazim DO. Stop chronic kidney disease progression: Time is approaching. World J Nephrol. 2016 May 6;5(3):258-273. doi:10.5527/wjn.v5.i3.258.
Chevalier RL. The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F145-161. doi:10.1152/ajprenal.00164.2016.
Sarvepalli PS, Fatima M, Quadri AK, et al. Study of therapeutic efficacy of febuxostat in chronic kidney disease stage IIIA to stage VD. Saudi J Kidney Dis Transpl. 2018 Sep-Oct;29(5):1050-1056. doi:10.4103/1319-2442.243953.
Savyc'ka LM. Rol' stanu funkcional'nogo nyrkovogo rezervu, rivniv sechovoi' kysloty ta magniju u progresuvanni hronichnoi' hvoroby nyrok: diss. kand. med. nauk. med. nauk [The role of functional renal reserve, uric acid and magnesium levels in the progression of chronic kidney disease. PhD in med sci diss.]. Zaporizhzhia; 2020. 21 p. (in Ukrainian).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 D.D. Ivanov, T.B. Bevzenko, S.V. Kushnirenko, S.A. Rotova
This work is licensed under a Creative Commons Attribution 4.0 International License.