Changes in Renal Vascular Endothelium and Indicators of Endothelial Vascular Dysfunction in Systemic Autoimmune Rheumatic Diseases

O.V. Syniachenko, Ye.D. Yehudina, T.B. Bevzenko, M.V. Yermolaieva, O.O. Diadyk, V.V. Yakovlenko


The objective of the work was to evaluate the nature of morphological changes in the endothelium of renal capillaries and arterioles in systemic lupus erythematosus, rheumatoid arthritis, hemorrhagic vasculitis and microscopic polyangiitis, the relationship with clinical and laboratory factors of the disease course and the impact of systemic vascular endothelial dysfunction. The latter takes place in 39, 35, 52 and 100 % of cases, respectively, in these groups of patients, it is involved in the pathogenetic constructions of nephropathy, is closely associated with systemic clinical and instrumental manifestations of angiopathy, and proliferation of capillary endothelium and renal arterioles, depositions in it of immunoglobulins and complement components, depending on the clinical entities of systemic autoimmune rheumatic diseases, determine the blood levels of vascular endothelial growth factor, endothelin-1, homocysteine, E- and P-selectin.


rheumatic diseases; kidneys; endothelium; vessels; function


Baerwald C, Kneitz C, Bach M, Licht M. Extra-articular manifestations of rheumatoid arthritis. Z Rheumatol. 2012;71(10):841-9. doi: 10.1007/s00393-011-0928-x.

De Groot K. Renal manifestations in rheumatic diseases. Internist, 2009;48(8):779-85.

Dey-Rao R, Sinha AA. Genome-wide transcriptional profiling data from chronic cutaneous lupus erythematosus (CCLE) peripheral blood. Data Brief. 2014;11(2):39-41. doi: 10.1016/j.dib.2014.11.006.

Ding Y, Liao W, Yi Z, Xiang W, He X. Association of miRNA-145 expression in vascular smooth muscle cells with vascular damages in patients with lupus nephritis. Int J Clin Exp Pathol. 2015;8(10):12646-56.

Elshabrawy HA, Chen Z, Volin MV, Ravella S, Virupannavar S, Shahrara S. The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis. 2015;18(4):433-48. doi: 10.1007/s10456-015-9477-2.

Ferrante A, Guggino G, Di Liberto D, Ciccia F, Cipriani P, Balistreri CR, Sireci G, Giacomelli R, Triolo G. Endothelial progenitor cells: Are they displaying a function in autoimmune disorders? Mech Ageing Dev. 2016;3(5):122-8. doi: S0047-6374(16)30056-2.

Fujita E, Nagahama K, Shimizu A, Aoki M, Higo S, Yasuda F, Mii A, Fukui M, Kaneko T, Tsuruoka S. Glomerular capillary and endothelial cell injury is associated with the formation of necrotizing and crescentic lesions in crescentic glomerulonephritis. J Nippon Med Sch. 2015;82(1):27-35. doi: 10.1272/jnms.82.27.

González-Suárez I, Arpa J, Ríos-Blanco JJ. Brain microvasculature involvement in ANCA positive vasculitis. Cerebrovasc Dis. 2016;41(5-6):313-21. doi: 10.1159/000443750.

Guo L, Li M, Chen Y, Wang Q, Tian Z, Pan S, Zeng X, Ye S. Anti-endothelin receptor type a autoantibodies in systemic lupus erythematosus-associated pulmonary arterial hypertension. Arthritis Rheumatol. 2015;67(9):2394-402. doi: 10.1002/art.39212.

Haavisto M, Saraste A, Pirilä L, Hannukainen JC, Kalliokoski KK, Kirjavainen A, Kemppainen J, Möttönen T, Knuuti J, Yli-Kerttula T, Roivainen A. Influence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis. Rheumatology. 2016;55(10):1777-85. doi: 10.1093/rheumatology/kew240.

Heijnen T, Wilmer A, Blockmans D, Henckaerts L. Outcome of patients with systemic diseases admitted to the medical intensive care unit of a tertiary referral hospital: a single-centre retrospective study. Scand J Rheumatol. 2016;45(2):146-50. doi: 10.3109/03009742.2015.1067329.

Hoffman GS, Calabrese LH. Vasculitis: determinants of disease patterns. Nat Rev Rheumatol. 2014;10(8):454-62. doi: 10.1038/nrrheum.2014.89.

Holle JU. ANCA-associated vasculitis. Internist 2015;56(1):41-50. doi: 10.1007/s00108-014-3613-8.

Iwasaki S, Suzuki A, Fujisawa T, Sato T, Shirai S, Kamigaki M, Otsuka N, Tomaru U, Ishizu A. Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report. Cardiovasc Pathol. 2015;24(6):408-10. doi: 10.1016/j.carpath.2015.07.005.

Kuo CF, Grainge MJ, Valdes AM, See LC, Luo SF, Yu KH, Zhang W, Doherty M. Familial aggregation of systemic lupus erythematosus and coaggregation of autoimmune diseases in affected families. JAMA Intern Med. 2015;175(9):1518-26. doi: 10.1001/jamainternmed.2015.3528.

Latuskiewicz-Potemska J, Chmura-Skirlinska A, Gurbiel RJ, Smolewska E. Nailfold capillaroscopy assessment of microcirculation abnormalities and endothelial dysfunction in children with primary or secondary Raynaud syndrome. Clin Rheumatol. 2016;35(8):1993-2001. doi: 10.1007/s10067-016-3340-8.

Maldonado A, Blanzari JN, Asbert P, Albiero JA, Gobbi C, Albiero E, Alba P. Medium vessel vasculitis in systemic lupus erythematosus. Rev Fac Cien Med Univ Nac Cordoba. 2016;73(1):50-2. PMID: 27419897

Marszałek A, Skoczylas-Makowska N, Kardymowicz A, Manitius J. Patient with rheumatoid arthritis and acute renal failure: a case report and review of literature. Pol J Pathol. 2010;61(4):229-33.

Palma Zochio Tozzato G, Taipeiro EF, Spadella MA, Marabini Filho P, de Assis MR, Carlos CP, Girol AP, Chies AB. Collagen-induced arthritis increases inducible nitric oxide synthase not only in aorta but also in the cardiac and renal microcirculation of mice. Clin Exp Immunol. 2016;183(3):341-9. doi: 10.1111/cei.12728.

Petrucci I, Samoni S, Meola M. Clinical scenarios in chronic kidney disease: parenchymal chronic renal diseases. Contrib Nephrol. 2016;188:98-107. doi: 10.1159/000445472.

Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, Trilla A, Stone JH, Khamashta MA, Shoenfeld Y. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015;14(8):670-9. doi: 10.1016/j.autrev.2015.03.008.

Rawlings CR, Fremlin GA, Nash J, Harding K. A rheumatology perspective on cutaneous vasculitis: assessment and investigation for the non-rheumatologist. Int Wound J. 2016;13(1):17-21. doi: 10.1111/iwj.12437.

Song D, Wu LH, Wang FM, Yang XW, Zhu D, Chen M, Yu F, Liu G, Zhao MH. The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther. 2013;15(1):12. doi: 10.1186/ar4142.

Tesar V, Hruskova Z. Conventional induction and maintenance treatment of antineutrophil cytoplasmic antibodies-associated vasculitis – still of value for our patients? Expert Opin Pharmacother 2015;16(11):1683-702. doi: 10.1517/14656566.2015.1059822.

Wilhelmus S, Alpers CE, Cook HT, Ferrario F, Fogo AB, Haas M, Joh K, Noël LH. The Revisited classification of GN in SLE at 10 years: Time to re-evaluate histopathologic lesions. J Am Soc Nephrol. 2015;26(12):2938-46. doi: 10.1681/ASN.2015040384.

Yang Z, Ren Y, Liu D, Lin F, Liang Y. Prevalence of systemic autoimmune rheumatic diseases and clinical significance of ANA profile: data from a tertiary hospital in Shanghai, China. APMIS. 2016;124(9):805-11. doi: 10.1111/apm.12564.

Yildiz A, Soydinc S. Diastolic dysfunction and endothelial dysfunction in systemic lupus erythematosus. Rheumatol Int . 2015;35(7):1281-2. doi: 10.1007/s00296-015-3220-6.



  • There are currently no refbacks.

Copyright (c) 2017 KIDNEYS

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2017


 Яндекс.МетрикаSeo анализ сайта Рейтинг