Changes in Renal Vascular Endothelium and Indicators of Endothelial Vascular Dysfunction in Systemic Autoimmune Rheumatic Diseases

O.V. Syniachenko, Ye.D. Yehudina, T.B. Bevzenko, M.V. Yermolaieva, O.O. Diadyk, V.V. Yakovlenko

Abstract


The objective of the work was to evaluate the nature of morphological changes in the endothelium of renal capillaries and arterioles in systemic lupus erythematosus, rheumatoid arthritis, hemorrhagic vasculitis and microscopic polyangiitis, the relationship with clinical and laboratory factors of the disease course and the impact of systemic vascular endothelial dysfunction. The latter takes place in 39, 35, 52 and 100 % of cases, respectively, in these groups of patients, it is involved in the pathogenetic constructions of nephropathy, is closely associated with systemic clinical and instrumental manifestations of angiopathy, and proliferation of capillary endothelium and renal arterioles, depositions in it of immunoglobulins and complement components, depending on the clinical entities of systemic autoimmune rheumatic diseases, determine the blood levels of vascular endothelial growth factor, endothelin-1, homocysteine, E- and P-selectin.

Keywords


rheumatic diseases; kidneys; endothelium; vessels; function

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DOI: https://doi.org/10.22141/2307-1257.6.1.2017.93783

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