Proteomics and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging as a Modern Diagnostic Tool in Kidney Diseases

Mariia Ivanova, Olena Dyadyk, Andrew Smith, Lucia Santorelli, Martina Stella, Manuel Galli, Clizia Chinello, Fulvio Magni

Abstract


As a result of the rapid evolution of modern science, we are continually improving our knowledge of disease pathogenesis and morphology on a daily basis. Due to the era of omics sciences, such as genomics, transcriptomics, and proteomics, there is a strong desire to comprehend the molecular mechanisms of diseases and organisms. The final aims would be to perform more successful diagnosis/prognosis, identify potential therapeutic targets, and predict treatment response. Chronic kidney disease (CKD) is a worldwide health problem with a rapidly increasing incidence, with CKD itself encompassing a large subset of diseases. Recently, modern proteomic technologies, such as matrix-assisted laser desorption/ionization mass spectrometry imaging, have been employed in order to study CKD. Notwithstanding the general infancy of these methodologies, there are already an impressive number of studies and publications related to this subject.


Keywords


сhronic kidney disease; proteomics; matrix-assisted laser desorption/ionization mass spectrometry imaging; сhronic kidney disease outcome prognosis; predict treatment response

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References


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DOI: https://doi.org/10.22141/2307-1257.6.1.2017.93780

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