The role of levocarnitine in the systemic therapy of patients of different profile of patients on chronic hemodialysis

M.D. Ivanova


The paper presents the pharmacological characteristics of L-carnitine and evaluation of the effectiveness of its application in nephrology practice. Discussed the evidence of the use of levocarnitine for chronic kidney disease and chronic renal failure.


L-carnitine; chronic kidney disease; chronic renal failure; therapy with L-carnitine in Nephrology


Levocarnitine - Compound Summary. PubChem. The National Library of Medicine (01.06.2005)

Berg JM Biochemistry - 5th Edition. — WH Freeman and Company, 2002. — P. 476. — ISBN 0-7167-4684-0

Carnitine (L-carnitine) | University of Maryland Medical Center

Ferrari R, Merli E, Cicchitelli G, Mele D, Fucili A, Ceconi C. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci. 2004 Nov;1033:79-91.

Tom L. Broderick, George Panagakis, Denise DiDomenico, James Gamble, Gary D. Lopaschuk, Austin L. Shug, Dennis J. Paulson. L-Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. Cardiovasc Res (1995) 30 (5):815-820.doi: 10.1016/S0008-6363(95)00111-5

James J. DiNicolantonio, PharmD; Carl J. Lavie, MD; Hassan Fares, MD;Arthur R. Menezes, MD; and James H. O’Keefe, MD. L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis. Mayo Foundation for Medical Education and Research n Mayo Clin Proc. 2013

Malaguarnera M, Gargante MP, Russo C, Antic T, Vacante M, Malaguarnera M, Avitabile T, Li Volti G, Galvano F. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial. Am J Gastroenterol. 2010 Jun;105(6):1338-45. doi: 10.1038/ajg.2009.719. Epub 2010 Jan 12.

Qian Jiang, Gang Jiang, Ke-qing Shi, Hong Cai, Yi-xin Wang, Ming-hua Zheng. Oral Acetyl-L-Carnitine treatment in hepatic encephalopathy: view of evidence-based medicine. Annals of Hepatology, 2013; 12 (5): 803-809.

Felker D, Lynn A, Wang S, Johnson DE. Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity. Expert Rev Clin Pharmacol. 2014 Jan 22. [Epub ahead of print]

Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007 Dec;86(6):1738-44.

Berni A, Meschini R, Filippi S, Palitti F, De Amicis A, Chessa L. L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells.Mutat Res. 2008 Feb 29;650(2):165-74. doi: 10.1016/j.mrgentox.2007.11.008. Epub 2007 Dec 8.

Charles Chazot. Carnitine supplementation in hemodialysis patients.

Ahmad S: L-carnitine in dialysis patients. Semin Dial 14:209-217., 2001

Hiatt WR, Koziol BJ, Shapiro JI, Brass EP: Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int 41:1613-1619., 1992

Chazot C, Jean G, Vo Van C, Charra B, Terrat JC, G. L: Serum carnitine as a marker of protein malnutrition (Abstract). J Am Soc Nephrol 8:230A, 1997

Constantin-Teodosiu D, Young S, Wellock F, Short AH, Burden RP, Morgan AG, Greenhaff PL: Gender and age differences in plasma carnitine, muscle strength, and exercise tolerance in haemodialysis patients. Nephrol Dial Transplant 17:1808-1813., 2002

Kudoh Y, Aoyama S, Torii T, Chen Q, Nagahara D, Sakata H, Nozawa A. Hemodynamic stabilizing effects of L-carnitine in chronic hemodialysis patients. Cardiorenal Med. 2013 Oct;3(3):200-7. doi: 10.1159/000355016. Epub 2013 Sep 27.

Lynch KE, Feldman HI, Berlin JA, Flory J, Rowan CG, Brunelli SMEffects Of L-Carnitine On Dialysis-Related Hypotension And Muscle Cramps: A Meta-Analysis. Source: Am. J. Kidney Dis. 2008; Nov;52(5):962-71; PMID: 18706751

Debska-Slizien A, Kawecka A, Wojnarowski K, Prajs J, Malgorzewicz S, Kunicka D, Zdrojewski Z, Lysiak-Szydlowska W, Lipinski J, Rutkowski B. Correlation between plasma carnitine, muscle carnitine and glycogen levels in maintenance hemodialysis patients. Int J Artif Or¬gans 2000, 23: 90-96.

Jean-Marc Hurot, Michel Cucherat,Margaret Haugh,Denis Fouque. Effects of l-Carnitine Supplementation in Maintenance Hemodialysis Patients: A Systematic Review

Labonia WD. L-carnitine effects on anemia in hemodialyzed patients treated with erythropoietin. Am J Kidney Dis 1995, 26: 757-764.

Hurot JM, Cucherat M, Haugh M, Fouque D: Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. J Am Soc Nephrol 13:708-714., 2002

National Kidney Foundation Carnitine Consensus Conference Practice Recommendations. American Journal of Kidney Diseases (2003; 41:868-876).

Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. Am J Kidney Dis 35:S1-140., 2000

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