Clinicomorphological Comparisons of Renal Pathology Signs in Hemorrhagic Vasculitis with Extrarenal Manifestations of the Disease
The aim of the work: to make comparison of the nature of renal pathology and clinical course of hemorrhagic vasculitis, to assess the correlation of extrarenal manifestations of the disease with morphological signs of glomerulonephritis.
Materials and Methods. The study involved 144 patients (56 % men and 44 % women). Morphological study of renal tissues was performed in 21 patients (12 men and 9 women) with preserved renal function and urinary syndrome. Glomerulonephritis was diagnosed in 65 % of examined patients, I–IV degree chronic renal failure — in 17 %, nephrotic syndrome — in 8 %. Morphological class of glomerulonephritis was larger in men.
Results and Discussion. According to the results of variance and correlation analysis, the incidence of glomerulonephritis is affected by the overall level of activity of hemorrhagic vasculitis, integrated severity of extrarenal manifestations of the disease, the severity of cardiac pathology, at that glomerular filtration rate depends on the parameters of anti-neutrophil cytoplasmic antibodies, effective renal plasma flow — on the levels of IgM and circulating immune complexes, renal vascular resistance — on the content of IgG, and fibrinogen, fibronectin, C-reactive protein and IgA levels in the blood depend on the changes in the kidneys. The degree of glomerular IgA deposits in mesangium and interstitium, the incidence of fibrinoid changes and lymphohistiocytic vascular infiltration, deposits of IgM in the capillary endothelium, IgA, C3- and C1q-components of complement in the tubules depend on the gender of patient, and the severity of the tubular component — on the age of the patient.
Conclusions. In hemorrhagic vasculitis, clinicomorphological nature of kidney damage in the form of glomerulonephritis correlates with extrarenal manifestations of the disease, the degree of disease activity and concentration of immune inflammatory proteins in the blood.
Full Text:PDF (Русский)
Дядык А.И. Системные васкулиты в современной клинической практике / А.И. Дядык, Л.С. Холопов, С.Р. Зборовский [и др.]. — Донецк: Издатель Заславский А.Ю., 2013. — 248 с.
Dudley J. Randomised, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schonlein purpura (HSP) / J. Dudley, G. Smith, A. Llewelyn-Edwards [et al.] // Arch. Dis. Child. — 2013. — Vol. 98, № 10. — P. 756-763.
Guo Y.N. The relationship between children kidney diseases and adult ESRD — an epidemiological investigation of 700 cases / Y.N. Guo, Z. Wang, J. Lu // Ren. Fail. — 2013. — Vol. 35, № 10. — P. 1353-1357.
Kawasaki Y. Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment / Y. Kawasaki, A. Ono, S. Ohara [et al.] // Fukushima J. Med. Sci. — 2013. — Vol. 59, № 1. — P. 15-26.
Lardhi A.A. Henoch-Schonlein purpura in children from the eastern province of Saudi Arabia / A.A. Lardhi // Saudi Med. J. — 2012. — Vol. 33, № 9. — P. 973-978.
Moore S. Henoch-Schonlein purpura / S. Moore, A. Bowden, S. Afify // BMJ Case Rep. — 2011. — Vol. 23. — P. 2011-2012.
Naija O. Predictive factors of severe Henoch-Schonlein nephritis in children: report of 34 cases / O. Naija, J. Bouzaraa, R. Goucha-Louzir, M.R. Lakhoua // Tunis Med. — 2012. — Vol. 90, № 12. — P. 878-881.
Yin X.L. Twenty-three-year review of disease patterns from renal biopsies: an experience from a pediatric renal center / X.L. Yin, M.S. Zou, Y. Zhang [et al.] // J. Nephrol. — 2013. — Vol. 26, № 4. — P. 699-707.
- There are currently no refbacks.
Copyright (c) 2016 KIDNEYS
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2018