Adsorptive-Rheological Properties of Blood Serum in Gouty Nephropathy

O.V. Sinyachenko, Yu.O. Bryzhataya, P.O. Sinyachenko

Abstract


The aim and tasks of the study — to evaluate clinical-pathogenetic significance of changes in adsorptive rheological properties of blood serum (ARPB) in patients with different clinical courses of gouty nephropathy. Material and methods. With the help of interfacial tensiorheometry of blood there have been examined 89 patients and 30 apparently healthy people of control group (mainly males). We have used computer devices MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface. Urolithic type of nephropathy has been diagnosed in 39 % of cases, latent one — in 61 %. Reduced kidney function was in 54 % of the examined patients. Results and their discussion. Type of gouty nephropathy has an significant impact on the integral parameters of urine determining the levels of proteinuria, leukocyturia, oxalaturia, uricuria, fibronectinuria, ­b2-microglobulinuria and nitrituria, clearance of creatinine, uric acid, oxypurinol and calcium, and urolithic type of kidney lesion is evident with higher, in comparison with latent type, surface tension of blood serum that is connected with parameters of kidneys function, has prognostic significance, influences the interfacial surface activity and viscoelastic urine properties. Conclusions. ARPB changes reflect the character of gouty nephropathy course, single indices take part in pathogenesis of the disease and might have prognostic significance.

Keywords


gout; nephropathy; blood; adsorption; rheology

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DOI: https://doi.org/10.22141/2307-1257.0.3.09.2014.76071

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