Renal Morphological Changes in Experimental Systemic Vasculitis: Relation to Nephrotoxic Microelements

T.B. Bevzenko

Abstract


In the experiments on rats with a model of systemic vasculitis, it is shown that exogenous load on the body of nephrotoxic microele­ments, such as cadmium, lithium and molybdenum, affects the integral morphological indicators of kidney structure lesions, in particular cases of thickened basement membrane of Shumlianskyi capsule became 6.7 times more frequent, the severity of arteriolar endothelial proliferation increased by 63 % and degenerative (atrophic) changes in the tubules — by 21 %.


Keywords


systemic vasculitis; experiment; animals; kidneys; morphology; nephrotoxic microelements

References


Akerstrom M. Sampling of urinary cadmium: differences between 24-h urine and overnight spot urine sampling, and impact of adjustment for dilution / M. Akerstrom, T. Lundh, L. Barregard, G. Sallsten // Int. Arch. Occup. Environ Health. — 2012. — Vol. 85, № 2. — P. 189-196.

Csernok E. Immunopathology of ANCA-associated vasculitis / E. Csernok, A. Muller, W. L. Gross // Intern. Med. — 2009. — Vol. 38, № 10. — P. 759-765.

Denys S. In vivo validation of the unified BARGE method to assess the bioaccessibility of arsenic, antimony, cadmium, and lead in soils / S. Denys, J. Caboche, K. Tack [et al.] // Environ Sci. Technol. — 2012. — Vol. 46, № 11. — P. 6252-6260.

Fujiwara Y. Cadmium renal toxicity via apoptotic pathways / Y. Fujiwara, J.Y. Lee, M. Tokumoto, M. Satoh // Biol. Pharm. Bull. — 2012. — Vol. 35, № 11. — P. 1892-1897.

Gena P. Cadmium impairs albumin reabsorption by down-regula­ting megalin and ClC5 channels in renal proximal tubule cells / P. Gena, G. Calamita, W.B. Guggino // Environ Health Perspect. — 2015. — Vol. 118, № 11. — P. 1551-1556.

Jerez S. Distribution of metals and trace elements in adult and juvenile penguins from the Antarctic Peninsula area / S. Jerez, M. Motas, J. Benzal [et al.] // Environ Sci. Pollut. Res. Int. — 2012. — Vol. 24, № 10. — P. 65-68.

Kala G.K. Lithium-induced membranous glomerulonephropathy in a pediatric patient / G.K. Kala, M. Mogri, E. Weber-Shrikant, J.E. Sprin­gate // Pediatr. Nephrol. — 2013. — Vol. 24, № 11. — P. 2267-2269.

Kim Y. Associations of blood lead, cadmium, and mercury with estimated glomerular filtration rate in the Korean general population: analysis of 2008-2010 Korean national health and nutrition examination survey data / Y. Kim, B.K. Lee // Environ Res. — 2012. — Vol. 118. — P. 124-129.

Kumar P. Footprints of air pollution and changing environment on the sustainability of built infrastructure / P. Kumar, B. Imam // Sci. Total. Environ. — 2012. — Vol. 20, № 444. — P. 85-101.

Markowitz G.S. Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy / G.S. Markowitz, J. Radhakrishnan, N. Kambham [et al.] // J. Am. Soc. Nephrol. — 2011. — Vol. 11, № 8. — P. 1439-1448.

Moyer C.F. Systemic vascular disease in male B6C3F1 mice exposed to particulate matter by inhalation: studies conducted by the National Toxicology Program / C.F. Moyer, U.P. Kodavanti, J.K. Haseman, D.L. Costa // Toxicol. Pathol. — 2009. — Vol. 30, № 4. — P. 427-434.

Nawrot T.S. Cadmium exposure in the population: from health risks to strategies of prevention / T.S. Nawrot, J.A. Staessen, H.A. Roels [et al.] // Biometals. — 2010. — Vol. 23, № 5. — P. 769-782.

Odubanjo M.O. End-stage renal disease in Nigeria: an overview of the epidemiology and the pathogenetic mechanisms / M.O. Odubanjo, C.A. Okolo, A.O. Oluwasola, A. Arije // Saudi J. Kidney Dis. Transpl. — 2011. — Vol. 22, № 5. — P. 1064-1071.

Rowaiye O.O. The kidneys and ANCA-associated vasculitis: from pathogenesis to diagnosis / O.O. Rowaiye, M. Kusztal, M. Klinger // Clin. Kidney J. — 2015. — Vol. 8, № 3. — P. 343-350.

Sabath E. Renal health and the environment: heavy metal nephrotoxicity / E. Sabath, M.L. Robles-Osorio // Nefrologia. — 2012. — Vol. 32, № 3. — P. 279-286.

Shelley R. Associations of multiple metals with kidney outcomes in lead workers / R. Shelley, N.S. Kim, P. Parsons [et al.] // Occup. Environ Med. — 2012. — Vol. 69, № 10. — P. 727-735.

Wakamatsu-Yamanaka T. Geographic differences in the increa­sing ESRD rate have disappeared in Japan / T. Wakamatsu-Yamanaka, M. Fukuda, R. Sato [et al.] // Clin. Exp. Nephrol. — 2011. — Vol. 15, № 5. — P. 708-713.




DOI: https://doi.org/10.22141/2307-1257.0.3.13.2015.74925

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