Renal Parenchymal Hypoxia in Young Children in the Period of Complete Remission of Acute Uncomplicated Pyelonephritis without Renal Impairment

N.S. Lukianenko, K.A. Kens, N.A. Petritsa


Introduction. After establishing the diagnosis of pyelonephritis, there is a need to determine, whether renal parenchymal hypoxia remains in the period of remission. The least studied methods up to now are functional ones, which allow to verify the presence and degree of tissue hypoxia in secondary pyelonephritis and to evaluate the results of the medical measures to restore kidney function. Objective: to clarify the presence of renal parenchymal hypoxia and membrane destruction of the renal epithelium in young children with pyelonephritis without anatomic congenital malformations of the urinary system during its remission.
Materials and methods of the study. The study involved 65 children with acute uncomplicated pyelonephritis, who after nephro-urological examination did not reveal anatomical malformations of the urinary system. General clinical examination was carried out, markers of tissue hypoxia and morphofunctional state of cell membranes of renal epithelium were determined.
Discussion of the study results. The ability of urine to prevent crystal formation was significantly reduced to oxalates and phosphates in 40.0 and 47.7 % of the surveyed children. In one-third of children with pyelonephritis, oxalate excretion was significantly higher than in healthy children, hypophosphaturia was detected in 52.3 % of cases and the tendency to reduce the excretion of urates in 10.8 % of pediatric patients with pyelonephritis. The content of lipid peroxidation products in urine was increased in 41.5 % of the surveyed children with pyelonephritis, and appearance of polar lipids was observed in 46.2 % of patients.
Conclusions. To predict the formation and for the purpose of early diagnosis of renal parenchymal hypoxia and the processes of nephrothelial membrane destruction in young children with pyelonephritis, it is recommended to use such markers, as indicators of urine ability to prevent crystal formation, daily excretion of salts, excretion of lipid peroxidation products and polar lipids in the urine. It is recommended to apply the methods to correct these changes.


young children; acute pyelonephritis


Bahdasarova IV, Budnik TV, Malakhova AV. [Diseases of the urinary system in children and connective tissue dysplasia syndrome]. Novosty medytsynы y farmatsyy. Nefrolohyya. 2009; (297):38–39.Ukrainian.

Vel'tyshchev YuE, Ananenko АА, Tytov HM. Byokhymycheskoe yssledovanye mochy u detey: Metod. rekomendatsyy [Biochemical urine in children: Metod. Rekomendatsyy]. M; 1979. 51p. Russian.

Buhayova, OV. [Comparison of clinical and biochemical phenotypes of the syndrome of Ehlers-Danlos syndrome] : avtoref. dys.. . kand. med. nauk: 03.00.15 ; Khark. med. akad. pislyadyplom. osvity MOZ Ukrayiny, Khark. nats. med. un-t. Kh.; 2009. 20 p. Ukrainian.

Ivanov DD. [Urinary tract infections in children: update 2012]. Novosty medytsynы y farmatsyy. 2013; (14):18 – 20. Ukrainian.

Kens KA. [Non-invasive markers of renal failure in young children with bladder-ureter reflux dynamics and metabolic surgical treatment] : avtoreferat dys. ... kand med. nauk : spets. 14.01.06; Derzhavna Ustanova «Instytut urolohiyi NAMN Ukrayiny». Kyyiv; 2012. 23p. Ukrainian.

Klymenko TM, Ahashkov VS, Karymov RI, Puzykova VV. [Clinical and biochemical determinants of connective tissue dysplasia in newborns]. Zdorov'e rebenka. 2009; (2):106 – 110. Ukrainian.

Luk'yanova LD. [Signal role of mitochondria in the adaptation to hypoxia]. Fiziolohichnyy zhurnal. 2013; 59(6):141-154. Russian.

Maydannyk VH, Burlaka YeA. [State-hypoxic metabolic disorders in diabetic nephropathy in children]. Eksperymental'na ta klinichna fiziolohiya i biokhimiya: nauk.-prakt. zhurnal. 2015; (4): 47-55. Ukrainian.

Aver'yanova NY, Balueva LH. [Oxalate crystalluria in children]. Mezhdunarodnыy zhurnal prykladnыkh y fundamental'nыkh yssledovanyy. 2012; (5): 25-27. Russian.

Topchyy YY, Kyryenko AN, Bondar' TN. [Peroxidation of lipids and metabolism of nitric oxide in patients with chronic kidney disease during the treatment]. Ukrayins'kyy zhurnal nefrolohiyi ta dializu. 2012; (1): 3-8. Russian.

Maydannyk VH, Burlaka YeA, Bahdasarova IV. [The role of hypoxia-induced apoptosis in progression of chronic glomerulonephritis in children]. Ukrayins'kyy zhurnal nefrolohiyi ta dializu. 2014; (4): 41-45. Ukrainian.

Ruda VI. [Social and medical-biological factors and markers of the risk of congenital nephropathy in children]. Perynatolohiya ta pediatriya. 2004; (1): 51-53. Ukrainian.

Seymivs'kyy DA. [The secondary pyelonephritis in children: pathogenesis, diagnosis, treatment]. Klinichna imunolohiya. Alerholohiya. Infektolohiya: Vydannya dlya likarya-praktyka. 2008; (1): 50-52. Ukrainian.

Yur'eva ЭA, Kazanskaya YV, Azyzov NV, authors. Skrynynh-testы dlya dyahnostyky metabolycheskykh narushenyy pry uro-nefrolohycheskykh zabolevanyyakh u detey: metod. rekomendatsyy [Screening tests for the diagnosis of metabolic disorders in the uro-neurological diseases in children: a method. recommendations]. M.; 1985. 10 p. Russian.

Hrebeshevoy YY. Skrynnynh-testы v pedyatryy [Screening tests in pediatrics]. K.; 1985. 30 p. Russian.

Solyeyko OV, Osypenko IP, Soleyko LP. ["Biochemical face" syndrome undifferentiated connective tissue dysplasia]. Liky Ukrayiny. 2014; (1): 6-14. Ukrainian.

Tryndyuk YuS. [Some aspects of diagnosis of pyelonephritis in children]. Zdorov'e rebenka. 2011; (5): 36 – 38. Ukrainian.

Copyright (c) 2016 KIDNEYS

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2019


   Seo анализ сайта