Acute Glomerulonephritis: Clinical and Pathologic Features (Case Report)

Main Article Content

O.O. Diadyk
L.H. Nekrasova
O.I. Taran
I.O. Siroshtanova
L.V. Kominko


Clinical observation demonstrates the case of acute postinfectious glomerulonephritis with its histopathological features with the preexisting injury of renal tubules — cystic kidney disease of undefined type. The patient Kh., 20 years old, received pathogenetic treatment of acute postinfectious glomerulonephritis by glucocorticoids and cytostatic drugs. Despite the therapy, glomerulonephritis clinical symptoms inexorably progressed, nephrotic syndrome developed, leading to critical loss of plasma proteins, coagulation system disorders like DIC-syndrome, with subsequent alignment of uremia. Presumably, glucocorticoid resistance is related to preexisting tubular injury, characterized by impaired function and, maybe, genetically determined factors, too.

Article Details

How to Cite
Diadyk, O., L. Nekrasova, O. Taran, I. Siroshtanova, and L. Kominko. “Acute Glomerulonephritis: Clinical and Pathologic Features (Case Report)”. KIDNEYS, no. 1.15, Feb. 2016, pp. 89-94, doi:10.22141/2307-1257.1.15.2016.71487.
Clinical Observation


Муравлева Л.Е., Молотов-Лучанский В.Б., Клюев Д.А. Гемостаз при хронической болезни почек. Миниобзор // Современные проблемы науки и образования. — 2010. — № 4. — С. 36-42.

Руководство по нефрологии / Под ред. А.И. Дядыка, Е.А. Дядык. — К.: Четверта хвиля, 2011. — С. 106-118, 452-476.

Сократов Н.В. Открытие новой биологической закономерности патогенеза нарушений системы гемостаза при заболеваниях почек // Современные проблемы науки и образования. — 2014. — № 2. — С. 77-80.

Atypical post-infectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement / Sanjeev S., F.C. Fervenza, Yuzhou Zhang, Ladan Zand, N.C. Meyer, Nicolò Borsa, S.H. Nasr, and R.J.H. Smith // Kidney Int. — 2013 February. — 83 (2). — Р. 293-299.

Тератология человека / Под ред. Г.И. Лазюка. — М.: Медицина, 1991. — С. 280-295.

The association of polymorphonuclears with humps in acute postinfectious glomerulonephritis / Mandache E., Penescu M.N. // Rom. J. Morphol. Embryol. — 2012. — 53 (3). — Р. 629-633.

Diagnostic Atlas of Renal Pathology / A.B. Fogo, M. Kashga­rian. — 2nd ed. — Elsevier, 2012. — P. 115-127.

Heptinstall’s Pathology of the Kidney / Ed. by J.C. Jennette, J.L. Olson, F.G. S.V.D. D’Agati. — 7th ed. — Wolter Kluwer, 2014. — Vol. 1 — P. 273-279.

Van Rossum E.F.C., Lamberts S.W.J. Glucocorticoid resistance syndrome: a diagnostic and therapeutic approach // Best practice & research Clinical endocrinology & metabolism. — 2006. — Vol. 20, № 4. — Р. 611-626.