Uric Acid and its Role in the Progression of Chronic Kidney Disease: Do We Know Enough?

L.M. Savytska


At the present stage of medical science development, the role of hyperuricemia as the factor of chronic kidney disease progression is actively discussed. Some epidemiological studies have been presented to evaluate the relationship between uric acid levels and the progression of disease. Despite their multiplicity, the data on the presence of this correlation, as well as on the impact of uric acid-lowering therapy remain very controversial and ambiguous. The causes are the variety in the endpoints of the studies, their insufficient duration or small number of participants, as well as the lack of researches of alternative medications. To clarify the prognostic significance of hyperuricemia and the need for its correction, further targeted studies are required.


uric acid; hyperuricemia; chronic kidney disease; progression


Kudaeva FM, Barskova VG, Gordeev AV.[Modern ideas about the factors causing the kidney damage in gout] .Terapevtitcheskij archiv. 2005;77(5):90-95. Russian

Іlnitska MR, Nikula TD, Moyseєnko VO, Kisіl SS.[Uric acid as a trigger of vascular pathology and chronic kidney disease]. Klіnіchna meditsina. 2011; 2:38-43. Ukrainian

Mukhin IV, Morozenko OV. [Modern understanding of the factors and mechanisms of the progression of chronic kidney disease and the main directions of renoprotection. Communication 1]. Ukrainsky jurnal nefrologії ta dіalіzu. 2007;3:45-49. Russian

Bobulescu I.A. Renal Transport of Uric Acid: Evolving Concepts and Uncertainties / Bobulescu IA, Orson WM. Adv Chronic Kidney Dis. 2012;19(6): 358–371, doi:10.1053/j.ackd.2012.07.009. English

Bose B. Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis / Bose B, Badve SV, Hiremath SS., Boudville N, Brown FG., Cass A, Zoysa JR, Fassett RG, Faull R, Harris DC, Hawley CM, Kanellis J, Palmer SC, Perkovic V, Pascoe EM, Rangan GK, Walker RJ, Walters G, Johnson DW. Nephrol. Dial. Transplant. 2014; 29:406-413, doi: 10.1093/ndt/gft378. English

Corry D.B. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system./ Corry DB; Pirooz E; Keib Y, Michael ND, Hirofumib M, Tuck ML. Hypertens. 2008;26:269–275, doi: 10.1097/HJH.0b013e3282f240bf. English

Giordano C. Uric Acid as a Marker of Kidney Disease: Review of the Current Literature/ Giordano C, Karasik O, King-Morris K, Asmar A.Hindawi Publishing Corporation Disease Markers Volume 2015, Article ID 382918, 6 pages

Jala D. I. Uric Acid as a Target of Therapy in CKD./ Jala DI, Chonchol M, Chen W, Targher G. Am J Kidney Dis. 2013;61(1):134–146, doi:10.1053/j.ajkd.2012.07.021. English

Johnson R. J. Uric acid and chronic kidney disease: which is chasing which?/ Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Nephrol. Dial. Transplant. 2013;28:2221–2228, doi: 10.1093/ndt/gft029. English

Kim I.Y. The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship/ Kim IY, Lee DW, Lee SB, Kwak IS//Hindawi Publishing Corporation. BioMed Research International.- Volume 2014, Article ID 638732, 9 pages English

KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease// Kidney international supplements. 2013; 3(1):1-73. English

Marks A. Definitions of progression in chronic kidney disease – predictors and relationship to renal replacement therapy in a population cohort with a 6 year follow-up / Marks A, Fluck N, Prescott GJ, Robertson LM, Simpson WG, Smith WC, Black C. Nephrol. Dial. Transplant. 2014; 29: 333-341, doi 10.1093/ndt/gft393. English

Mazzali M. Elevated uric acid increases blood pressure in the rat by a novel crystalindependent mechanism./M. Mazzali, J. Hughes, Y.-G. Kim. Hypertension. 2001;38(5): 1101–1106, PMID: 11711505. English

Momeni A. Effect of allopurinol in decreasing proteinuria in type 2 diabetic patients./ Momeni A, Shahidi S, Seirafian S, Taheri S, Kheiri S. Iran J Kidney Dis. 2010;4(2):128-132, PMID: 20404423. English

Nacak H. Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease / Nacak H, Diepen M,. Qureshi AR, Carrero JJ, Stijnen T,. Dekker FW, Evans M. Nephrol. Dial. Transplant. 2015;30: 2039-2045, doi: 10/1093/ndt/gfv225. English

National Kidney Foundation. KDOQI Clinical Practice Guidelines for chronic kidney disease: evaluation, classification and stratification. Am J Kidney Dis. 2002;39:1-266. English

Prasad O.S. Associations Between Hyperuricemia and Chronic Kidney Disease: A Review/ Om Shankar Prasad Sah, Yu Xue Qing Sah. Nephro Urol Mon. 2015;7(3):e27233, doi: 10.5812/numonthly. English

Ryu E. S. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease/ Ryu ES, MJ Kim, HS Shin. The American Journal of Physiology.Renal Physiology. 2013; 304(5):471–480, doi: 10.1152/ajprenal.00560.2012. English

Shi Y. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial. /Shi Y, Chen W, Jalal D, Li Z, Chen W, Mao H, Yang Q, Johnson RJ, Yu X. Kidney Blood Press Res.2012;35(3):153-160. doi: 10.1159/000331453. English

Siu Y. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level./ Siu YP, Leung KT, Tong MK. Am J Kidney Dis. 2006;47:51–59, PMID: 16377385. English

Filiopoulos V. New Insights into Uric Acid Effects on the Progression and Prognosis of Chronic Kidney Disease./ Filiopoulos V, Hadjiyannakos D, Vlassopoulos D. Renal Failure. 2012;34(4):510–520, doi: 10.3109/0886022X.2011.653753. English

Tadashi Toyama. Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. / Toyama T, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, Mano T, Kaneko S, Wada T PLoS One. 2015;10(9): e0137449. doi: 10.1371/journal.pone.0137449. English

Copyright (c) 2016 KIDNEYS

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2019


   Seo анализ сайта