Future of Solid Organ Transplantation: Organ-Specific Tolerance

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Yusuf Ercin Sonmez


A transplant between two people who are not genetically identical is called an allotransplant and the process is called allotransplantation. Donor organs and tissues can be from people who are living, or people who have died because of a significant brain injury or lack of circulation. Allotransplantation can create a rejection process where the immune system of the recipient attacks the foreign donor organ or tissue and destroys it. The recipient may need to take immunosuppressive medication for the rest of their life to reduce the risk of rejection of the donated organ. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. The adverse effects associated with these agents and the risks of long-term immunosuppression present a number of challenges for the clinician. Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism.

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Sonmez, Y. E. “Future of Solid Organ Transplantation: Organ-Specific Tolerance”. KIDNEYS, vol. 10, no. 3, Sept. 2021, pp. 130-6, doi:10.22141/2307-1257.10.3.2021.239589.
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