Recurrent urinary tract infections: evidence base and debatable issues in non-antibacterial prevention
Keywords:recurrent urinary tract infections, women, forinal
AbstractRecurrent urinary tract infection (UTI) is a highly prevalent, costly, and burdensome condition affecting women of all ages, races, and ethnicities without regard for socioeconomic status, or educational level. Modern strategies aimed at preventing recurrent UTI are still not optimal, as evidenced by the relatively high prevalence of this nosology in women. The purpose of this article was to highlight and discuss both the evidence base and a number of unresolved issues in the management of recurrent UTI. The following topics of clinical interest are considered: diagnosis, age-related associations, continuous and intermittent antimicrobial prophylaxis, the effectiveness of modern non-antimicrobial prophylaxis, the potential role of forinal (a complex of D-mannose and cranberry fruit extract) in the prevention of recurrent UTI.
Bonkat G, Bartoletti R, Bruyere F, et al. Urological Infections: EAU Guidelines 2020. Available from: https://uroweb.org/guideline/urological-infections/.
National Institute for Health and Care Excellence (NICE). Urinary tract infection (recurrent): antimicrobial prescribing: NICE guideline [NG112]. Available from: https://www.nice.org.uk/guidance/ng112. Accessed: October 31, 2018.
Perepanova TS, Kozlov RS, Rudnov VA, Siniakova LA, Palagin IS. Antimikrobnaia terapiia i profilaktika infektsii pochek, mochevyvodiashchikh putei i muzhskikh polovykh organov: Federal'nye klinicheskie rekomendatsii [Antimicrobial therapy and prevention of infections of the kidneys, urinary tract and male genital organs]. Moscow; 2020. 63 р. (in Russian).
Torshin IYu, Apolikhina IА, Gromov AN, Gromova OA. Concerning the properties of D-mannose: anti-inflammatory and antitumor effects. Experimental and clinical urology. 2020;(2):164-170. doi:10.29188/2222-8543-2020-12-2-164-170. (in Russian).
Gan J, Dou Y, Li Y, et al. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials. 2018 Sep;178:95-108. doi:10.1016/j.biomaterials.2018.06.015.
González de Llano D, Moreno-Arribas MV, Bartolomé B. Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations. Molecules. 2020 Aug 1;25(15):3523. doi:10.3390/molecules25153523.
Copyright (c) 2020 S.O. Vozianov, D.D. Ivanov, S.V. Kushnirenko, O.O. Shevchuk, V.O. Mazurets, O.V. Kushnirenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.