Laсtiale Uro in the prevention of postmenopausal urinary infection: LACMUS study results


  • D.D. Ivanov Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • O.M. Korzh Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine



Lactobacilli, urinary tract infection, postmenopausal period


Background. The purpose was to assess the efficacy and safety of Lactiale Uro, a product containing two strains of Lactobacilli plus cranberry extract and vitamin A, in preventing recurrent urinary tract infections (UTIs) in postmenopausal women (LACMUS study). Materials and methods. This was a randomized, prospective, multicenter study. Subjects received Lactiale Uro twice daily for 26 weeks after recovery from UTI; the control group didn’t receive the product. The primary endpoint was the proportion of subjects with recurrent UTI episodes at the end of the study. Results. Seventy-seven women were screened; 65 were enrolled; 61 completed the study. After 26 weeks, a significantly lower number of women experienced recurrent UTIs with Lactiale Uro compared to no treatment (9.7 vs 23.3 %; P < 0.05). Lactiale Uro produced statistically significant improvements, such as lower rates of UTI episodes (12.9 vs 36.6 %; P < 0.05); longer time to first UTI episode (136 vs 27 days; P = 0.0038); shorter duration of active UTI episode (5 vs 11 days; P = 0.0199); and shorter duration of antibacterial therapy for an active UTI episode (4 vs 10 days; P = 0.0462). Conclusions. Lactiale Uro was safe and effective for the prevention of recurrent UTIs in postmenopausal women. These data require further well-designed trials to clarify possible benefits.


Ammon A. Antibiotic stewardship: A crucial task to counter multidrug-resistant bacteria. Available from: Accessed: December 11, 2017.

Grabe M, Bjerklund-Johansen TE, Botto H, et al. Guidelines on Urological Infections. Arnhem, the Netherlands: EAU; 2013. 106 p.

Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012 Oct 17;10(10):CD001321. doi:10.1002/14651858.CD001321.pub5.

Koradia P, Kapadia S, Trivedi Y, Chanchu G, Harper A. Probiotic and cranberry supplementation for preventing recurrent uncomplicated urinary tract infections in premenopausal women: a controlled pilot study. Expert Rev Anti Infect Ther. 2019 Sep;17(9):733-740. doi:10.1080/14787210.2019.1664287.

Bonkat G, Bartoletti RR, Bruyère F, et al. EAU Guidelines on Urological Infections. Arnhem, the Netherlands: EAU; 2019. 60 p.

Social Science Statistics. Chi-Square Test Calculator. Available from:

Asadi Karam MR, Habibi M, Bouzari S. Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli. Mol Immunol. 2019 Apr;108:56-67. doi:10.1016/j.molimm.2019.02.007.

Ivanov DD, Ivanova TP, Fedorenko OG, Kushnirenko SV, Ivanova MD. Options of modern anti-relapse therapy for urinary tract infections in children: CRUTIL trial. Počki. 2019;8(2):80-87. doi:10.22141/2307-1257.8.2.2019.166663. (in Ukrainian).

Ivanov DD. Phytotherapy and treatment of cystitis: current trends. 2019;8(2):196-200. doi:10.22141/2307-1257.8.4.2019.185117. (in Ukrainian).

Ivanov D, Abramov-Sommariva D, Moritz K, Eskötter H, Kostinenko T, Martynyuk L. An open label, non-controlled, multicentre, interventional trial to investigate the safety and efficacy of Canephron® N in the management of uncomplicated urinary tract infections (uUTIs).  Clin Phytosci. 2015;(1):7. doi:10.1186/s40816-015-0008-x.

Hannan TJ, Hooton TM, Hultgren SJ. Estrogen and recurrent UTI: what are the facts? Sci Transl Med. 2013 Jun 19;5(190):190fs23. doi:10.1126/scitranslmed.3006423.

Lüthje P, Brauner H, Ramos NL, et al. Estrogen supports urothelial defense mechanisms. Sci Transl Med. 2013 Jun 19;5(190):190ra80. doi:10.1126/scitranslmed.3005574.






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