Laсtiale Uro in the prevention of postmenopausal urinary infection: LACMUS study results

Authors

  • D.D. Ivanov Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine http://orcid.org/0000-0003-2609-0051
  • O.M. Korzh Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

DOI:

https://doi.org/10.22141/2307-1257.9.4.2020.218235

Keywords:

Lactobacilli, urinary tract infection, postmenopausal period

Abstract

Background. The purpose was to assess the efficacy and safety of Lactiale Uro, a product containing two strains of Lactobacilli plus cranberry extract and vitamin A, in preventing recurrent urinary tract infections (UTIs) in postmenopausal women (LACMUS study). Materials and methods. This was a randomized, prospective, multicenter study. Subjects received Lactiale Uro twice daily for 26 weeks after recovery from UTI; the control group didn’t receive the product. The primary endpoint was the proportion of subjects with recurrent UTI episodes at the end of the study. Results. Seventy-seven women were screened; 65 were enrolled; 61 completed the study. After 26 weeks, a significantly lower number of women experienced recurrent UTIs with Lactiale Uro compared to no treatment (9.7 vs 23.3 %; P < 0.05). Lactiale Uro produced statistically significant improvements, such as lower rates of UTI episodes (12.9 vs 36.6 %; P < 0.05); longer time to first UTI episode (136 vs 27 days; P = 0.0038); shorter duration of active UTI episode (5 vs 11 days; P = 0.0199); and shorter duration of antibacterial therapy for an active UTI episode (4 vs 10 days; P = 0.0462). Conclusions. Lactiale Uro was safe and effective for the prevention of recurrent UTIs in postmenopausal women. These data require further well-designed trials to clarify possible benefits.

References

Ammon A. Antibiotic stewardship: A crucial task to counter multidrug-resistant bacteria. Available from: https://uroweb.org/antibiotic-stewardship-a-crucial-task-to-counter-multidrug-resistant-bacteria/. Accessed: December 11, 2017.

Grabe M, Bjerklund-Johansen TE, Botto H, et al. Guidelines on Urological Infections. Arnhem, the Netherlands: EAU; 2013. 106 p.

Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012 Oct 17;10(10):CD001321. doi:10.1002/14651858.CD001321.pub5.

Koradia P, Kapadia S, Trivedi Y, Chanchu G, Harper A. Probiotic and cranberry supplementation for preventing recurrent uncomplicated urinary tract infections in premenopausal women: a controlled pilot study. Expert Rev Anti Infect Ther. 2019 Sep;17(9):733-740. doi:10.1080/14787210.2019.1664287.

Bonkat G, Bartoletti RR, Bruyère F, et al. EAU Guidelines on Urological Infections. Arnhem, the Netherlands: EAU; 2019. 60 p.

Social Science Statistics. Chi-Square Test Calculator. Available from: https://www.socscistatistics.com/tests/chisquare2/default2.aspx.

Asadi Karam MR, Habibi M, Bouzari S. Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli. Mol Immunol. 2019 Apr;108:56-67. doi:10.1016/j.molimm.2019.02.007.

Ivanov DD, Ivanova TP, Fedorenko OG, Kushnirenko SV, Ivanova MD. Options of modern anti-relapse therapy for urinary tract infections in children: CRUTIL trial. Počki. 2019;8(2):80-87. doi:10.22141/2307-1257.8.2.2019.166663. (in Ukrainian).

Ivanov DD. Phytotherapy and treatment of cystitis: current trends. 2019;8(2):196-200. doi:10.22141/2307-1257.8.4.2019.185117. (in Ukrainian).

Ivanov D, Abramov-Sommariva D, Moritz K, Eskötter H, Kostinenko T, Martynyuk L. An open label, non-controlled, multicentre, interventional trial to investigate the safety and efficacy of Canephron® N in the management of uncomplicated urinary tract infections (uUTIs).  Clin Phytosci. 2015;(1):7. doi:10.1186/s40816-015-0008-x.

Hannan TJ, Hooton TM, Hultgren SJ. Estrogen and recurrent UTI: what are the facts? Sci Transl Med. 2013 Jun 19;5(190):190fs23. doi:10.1126/scitranslmed.3006423.

Lüthje P, Brauner H, Ramos NL, et al. Estrogen supports urothelial defense mechanisms. Sci Transl Med. 2013 Jun 19;5(190):190ra80. doi:10.1126/scitranslmed.3005574.

Downloads

Published

2020-09-01

Issue

Vol. 9 No. 4 (2020)

Section

Original Articles

License

Copyright (c) 2020 D.D. Ivanov, O.M. Korzh

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our edition uses the copyright terms of Creative Commons for open access journals.

Authors, who are published in this journal, agree with the following terms:

  1. The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
  2. Directing  the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
  3. The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
  4. The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
  5. The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
  6. The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
  7. The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.