Renoprotection and its association with eGFR and renal functional reserve

D.D. Ivanov, A.I. Gozhenko, L.N. Savitskaya


Renoprotection is a system of measures for primarily pharmacological control, contributing to the continued preservation of renal function. When choosing renoprotection tactics, it is necessary to consider not only the estimated GFR (using the EPI formula), but also a functional renal reserve. The method of determining the renal reserve with oral administration of 0.45–0.50% sodium chloride solution at the rate of 0.5 % of body weight is considered to be physiologically substantiated. The renal reserve determining based on this technique as a routine method for examining nephrological patients provides additional information not only on the number of functioning nephrons, but also on their condition. A differentiated approach to prescribing renoprotective agents has been proposed, taking into account the stage of the disease and the functional renal reserve for maximum preservation of functioning nephrons.


chronic kidney disease; eGFR; functional renal reserve; renoprotection; RAAS blockers

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