The use of immunobiological monoclonal antibody-based drugs in nephrological practice

O.O. Melnyk

Abstract


With various diseases of the kidneys, immunobiological monoclonal antibody-based therapy with a different mechanism of action is successfully used. These drugs include: rituximab (interaction with the CD20 receptor and elimination of B cells), eсulizumab (inhibition of C5 complement clea­vage), burosumab (blocking fibroblast growth factor 23), adalimumab (anti-tumor necrosis factor α agent), abatacept (blocks co-stimulation of T cells by binding to CD80), fresolimumab (neutralization of transforming growth factor β). These drugs are used for systemic kidney diseases, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, kidney transplantation.

Keywords


kidney diseases; monoclonal antibodies; rituximab; eculizumab; burosumab; adalimumab; abatacept; fresolimumab

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DOI: https://doi.org/10.22141/2307-1257.7.3.2018.140208

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