Resistance of bacteria isolated in urinary tract infections to antimicrobial drugs in children

A.A. Vodianyk, Y.O. Grechukha, V.A. Ponyatovskiy, A.V. Gniloskurenko, I.O. Mitiuriaeva-Kornijko

Abstract


Background. Urinary tract infection (UTI) is one of the main causes of hospitalization of children. One of the main causes of ineffective treatment of UTI in children is the antibiotic resistance of UTI pathogens. The purpose of the study was to determine the prevalence of antibiotic resistance among pathogens of urinary tract infection. Materials and methods. An antibiotic resistance study was conducted on 61 clinical isolates that were isolated from urine specimens of children hospitalized with various forms of UTI. Thesensitivity to 23 antimicrobial drugs was studied using the method of antimicrobial discs, followed by the definition of inhibition zones. Results. The group of aminoglycosides was most effective against the pathogens of urinary tract infections (amikacin was effective to 91.9 % of clinical isolates, gentamicin — 82 %). Cephalosporins of III generation had different levels of antibiotic resistance, ranging from 11.8 % (ceftizoxime) to 42.5 % in cefpodoxime. A high level of sensitivity to synthetic antimicrobials was detected: sensitivity to furagin was 89.8 %, phosphomycin 86.5 %. Conclusions. The level of antibiotic resistance to UTI pathogens varies greatly in various antibacterial drugs, as well as depending on the form of UTI, therefore the study of antibiotic resistance is an important step in the treatment of patients with UTI.


Keywords


urinary tract infection; antibiotic resistance

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DOI: https://doi.org/10.22141/2307-1257.7.1.2018.122217

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