Resistance of bacteria isolated in urinary tract infections to antimicrobial drugs in children
Background. Urinary tract infection (UTI) is one of the main causes of hospitalization of children. One of the main causes of ineffective treatment of UTI in children is the antibiotic resistance of UTI pathogens. The purpose of the study was to determine the prevalence of antibiotic resistance among pathogens of urinary tract infection. Materials and methods. An antibiotic resistance study was conducted on 61 clinical isolates that were isolated from urine specimens of children hospitalized with various forms of UTI. Thesensitivity to 23 antimicrobial drugs was studied using the method of antimicrobial discs, followed by the definition of inhibition zones. Results. The group of aminoglycosides was most effective against the pathogens of urinary tract infections (amikacin was effective to 91.9 % of clinical isolates, gentamicin — 82 %). Cephalosporins of III generation had different levels of antibiotic resistance, ranging from 11.8 % (ceftizoxime) to 42.5 % in cefpodoxime. A high level of sensitivity to synthetic antimicrobials was detected: sensitivity to furagin was 89.8 %, phosphomycin 86.5 %. Conclusions. The level of antibiotic resistance to UTI pathogens varies greatly in various antibacterial drugs, as well as depending on the form of UTI, therefore the study of antibiotic resistance is an important step in the treatment of patients with UTI.
Full Text:PDF (Українська)
Koçak M, Büyükkaragöz B, Çelebi Tayfur A, et al. Causative pathogens and antibiotic resistance in children hospitalized for urinary tract infection. Pediatr Int. 2016 Jun;58(6):467-71. doi: 10.1111/ped.12842.
Faust WC, Diaz M, Pohl HG. Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature. J Urol. 2009 Jan;181(1):290-7; discussion 297-8. doi: 10.1016/j.juro.2008.09.039.
Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics. 2010 Dec;126(6):1084-91. doi: 10.1542/peds.2010-0685.
Kutasy B, Coyle D, Fossum M. Urinary Tract Infection in Children: Management in the Era of Antibiotic Resistance-A Pediatric Urologist's View. Eur Urol Focus. 2017 Apr;3(2-3):207-211. doi: 10.1016/j.euf.2017.09.013.
Lohr J, Downs S, Schlager T. Genitourinary tract infections, urinary tract infections. In: Long SS, Pickering LK, Prober CG, editors. Principles and Practice of Pediatric Infectious Diseases, 3rd ed. Philadelphia: Churchill Livingstone Elsevier; 2008. 343-347pp.
Linhares I, Raposo T, Rodrigues A, Almeida A. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a 10-year surveillance study (2000–2009). BMC Infect Dis. 2013 Jan 18;13:19. doi: 10.1186/1471-2334-13-19.
Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management, Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011 Sep;128(3):595-610. doi: 10.1542/peds.2011-1330.
CLSI. Performance standards for antimicrobial susceptibility testing: twenty-fifth informational supplement. CLSI document M100-S25. Wayne, PA: Clinical and Laboratory Standards Institute; 2015. 240 p.
Gupta K1, Hooton TM, Naber KG, et al. International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases, Clin Infect Dis. 2011 Mar 1;52(5):e103-20. doi: 10.1093/cid/ciq257.
Zhanel GG, Hisanaga TL, Laing NM, et al. Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents. 2006 Jun;27(6):468-75.
Yüksel S, Oztürk B, Kavaz A, et al. Antibiotic resistance of urinary tract pathogens and evaluation of empirical treatment in Turkish children with urinary tract infections. Int J Antimicrob Agents. 2006 Nov;28(5):413-6. doi: 10.1016/j.ijantimicag.2006.08.009.
Alós JI, Serrano MG, Gómez-Garcés JL, Perianes J. Antibiotic resistance of Escherichia coli from community-acquired urinary tract infections in relation to demographic and clinical data. Clin Microbiol Infect. 2005 Mar;11(3):199-203. doi:10.1111/j.1469-0691.2004.01057.x.
Ironmonger D, Edeghere O, Bains A, Loy R, Woodford N, Hawkey PM. Surveillance of antibiotic susceptibility of urinary tract pathogens for a population of 5.6 million over 4 years. J Antimicrob Chemother. 2015;70(6):1744-50. doi: 10.1093/jac/dkv043.
Copyright (c) 2018 KIDNEYS
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2020