Morphological features of kidneys in fetuses and newborns from mothers with subacute infectious-inflammatory process in the abdominal cavity caused by Escherichia coli (experimental study)

I.V. Sorokina, M.S. Myroshnychenko, M.D. Ivanova

Abstract


Background. In Ukraine, every year the number of women whose pregnancy occurs on the background of chronic infectious diseases increases. Escherichia coli is a frequent causative agent of bacterial infections in women. The purpose of the study was to identify the morphological features of fetuses and newborns kidneys from mothers with an experimental abdominal subacute infectious-inflammatory process caused by Esche­richia coli. Materials and methods. The authors conduc­ted an experiment on WAG rats, during which two groups were formed: group I — 7 fetuses and 11 newborns from 3 healthy females; group II — 10 fetuses and 13 newborns from 4 females with an abdominal infectious-inflammatory process in the abdominal cavity caused by Escherichia coli. The material of the study was the kidneys of fetuses and newborns. The authors used histological, histochemical, morphometric and statistical methods of investigation. Results. The abdominal subacute infectious-inflammatory process in the mother’s body caused by Escherichia coli leads to structural changes in the parenchymal and stromal components of the kidneys that have been growing from the fetus to the newborn. The glomerular apparatus of the kidneys is characterized by uneven distribution in the cortical layer, developmental delay, shape change, hemodynamic disorders, expansion of the urinary space, absence of capillaries, a decrease in the number and localization compactness of capillaries in some young and mature renal corpuscles; the tubular apparatus — developmental delay, shape change and focal thickening of the basal membranes of some tubules, focal dystrophic, necrotic and desquamative changes in the epithelium; stromal component — sclerotic changes, hemodynamic disorders, which were more pronounced in the medulla layer, cellular infiltration, characterized by the presence of fibroblastic cells and immune cells. Conclusions. Histological and morphometric changes in the fetuses and newborns kidneys developed due to the presence in mothers an experimental subacute infectious-inflammatory process in the abdominal cavity caused by Escherichia coli will lead to reduced functional abilities of the kidneys as a homeostatic organ and development of various nephrologic pathologies in such children.


Keywords


Escherichia coli; mother; kidney; fetus; newborn; morphology

References


Simrok VV, Slaepichko UN, Zhmurko TP, Averina AA. Perinatal mortality: cause, risk factor, prophylaxis. Tavricheskiy Mediko-Biologicheskiy Vestnik. 2012;15(2-1):280-282. (in Russian).

Samokhvalova AV. Characteristics of early neonatal period in newborns from mothers with reproductive losses and TORCH-infections. Aktual'ni pytannja pediatrii', akusherstva ta ginekologii'. 2013;1:97-99. (in Ukrainian).

Kim EI. Sostoianie zdorov'ia detei rannego vozrasta iz gruppy riska razvitiia vnutriutrobnykh infektsii. Diss. kand. med. nauk [State of young children health from the risk group of developing intrauterine infections. PhD diss.]. Khabarovsk; 2007. 26 p. (in Russian).

Iotenko BA, Demina TN, Mezhova OK. Influence of infection on the development of chronic placental insufficiency. Novosti Meditsiny i Farmatsii: Ginekologiia. 2008;253:38-43. (in Russian).

Makarov IO, Borovkova EI, Shemanaeva TV, Sotsuk AG. Fetoplacental insufficiency of infectious genesis: the role of chlamydial infection. Reproductive Endocrinology. 2012;6(8):79-82. doi: 10.18370/2309-4117.2012.8.79-82. (in Russian).

Zhabchenko ІА. Uropathogenic stamms of Escherichia coli: features of functioning, factors of virulence, value in clinical practice. Tavricheskiy Mediko-Biologicheskiy Vestnik. 2013;16:2(2):201-206. (in Russian).

Shipitsyna EV, Khusnutdinova TA, Savicheva AM, Ayvazyan TA. Urinary tract infections in obstetrics and gynecology. Journal of obstetrics and woman disease. 2015;64(6):91-104. doi: 10.17816/JOWD64691-104. (in Russian).

Skliarov IuI, Pravotorov GV, Balueva OI, et al. Morpho-functional characteristic of kidneys in mother, fetus and the offspring subjected to vibration of industrial frequency during gestation. Morfologiia. 2005;128(4):29-32. (in Russian).

Markovs'kyj VD, Sorokina IV, Kaluzhyna OV, et al. Sposib modeljuvannja vnutrishn'outrobnogo infikuvannja ploda ta novonarodzhenogo jak naslidku pidgostrogo infekcijno-zapal'nogo procesu materi [Method of modeling of intrauterine infection of the fetus and the newborn as a consequence of the subacute infectious-inflammatory process of the mother]. Patent UA № 108806, 2014. (in Ukrainian).

Barinov EF, Sulaeva ON. Morphometric characteristics of nephrogenic kidney zone of newborn rats. Morfologiia. 2003;123(2):77-79. (in Russian).

Tank KC, Saiyad SS, Pandya AM, Akbari VJ, Dangar KP. A study of histogenesis of human fetal kidney. Int J Biol Med Res. 2012; 3(1):1315-1321.

Lonergan GJ, Martínez-León MI, Agrons GA, Montemarano H, Suarez ES. Nephrogenic rests, nephroblastomatosis and associated lesions of the kidney. Radiographics. 1998 Jul-Aug;18(4):947-68. doi: 10.1148/radiographics.18.4.9672980.

Quaggin SE, Kreidberg JA. Development of the renal glomerulus: good neighbors and good fences. Development. 2008 Feb;135(4):609-20. doi: 10.1242/dev.001081.

Dorzhu UV, Shoshenko KA, Belichenko VM, Ayzman RI. The ontogenic changes of the kidney structure parameters at the rats. 2014;12(6):1201-1206. (in Russian).

Abdullina GA, Safina AI, Daminova MA. Clinical physiology of the kidneys in premature: the role of follow-up. Vestnik Sovremennoi Klinicheskoi Mediciny. 2014;7(6):9-13. (in Russian).

Franco MC, Oliveira V, Ponzio B, Rangel M, Palomino Z, Gil FZ. Influence of birth weight on the renal development and kidney diseases in adulthood: experimental and clinical evidence. Int J Nephrol. 2012;2012:608025. doi: 10.1155/2012/608025.

Rodríguez MM, Gómez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol. 2004 Jan-Feb;7(1):17-25. doi: 10.1007/s10024-003-3029-2.

Vinogradova MS, Boyarskaya AR, Ivanova LN. Peculiarities of the prenatal kidney ontogenesis of Wistar rats and Vasopressine-deficient Brattleboro rats. Vestnik NGU. Biologiia, klinicheskaia meditsina. 2010;8(1):45-50. (in Russian).

Bazhenov DV, Vikhareva LV, Panteleyev SM, Yanin VL, Yaroslavtseva OF. The sequence of nephron tubule differentiation in the definitive human kidney during the fetal period. Morfologiia. 2011;140(5):18-21. (in Russian).

Ukey RK, Waheed ARA, Laeeque M, Diwan CV. Histogenesis of human fetal renal cortex. International Journal of Recent Trends in Science and Technology. 2014;9(3):378-385.

Markovsky VD, Sorokina IV, Myroshnychenko MS, Pliten ON. Infectious pathology of mother and its influence on the anthropometric parameters of newborns. Annals of Mechnikov Institute. 2014;1:27-32. (in Russain).

Markovsky VD, Sorokina IV, Mishina MM, et al. Modeling subacute (prolonged) infectious inflammatory process in female of WAG rats. Neonatology, surgery and perinatal Medicine. 2014;4(14):60-65. (in Ukrainian).

Thompson L, Crimmins S, Telugu B, Turan S. Intrauterine hypoxia: clinical consequences and therapeutic perspectives. Research and Reports in Neonatology. 2015;5:79-89. doi: 10.2147/RRN.S57990.




DOI: https://doi.org/10.22141/2307-1257.7.1.2018.122216

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