Protein Klotho and FGF23 fibroblasts growth factor as markers of chronic renal disease

A.A. Melnik


Chronic kidney disease (CKD) is a global public health problem in the world. Research scientists are aimed at finding new biomarkers for CKD. Such biomarkers are α-Klotho soluble protein and fibroblast growth factor (FGF23). It was shown that the expression of Klotho protein decreases progressively as the progression of CKD and reaches low or undetectable values at the terminal stage of kidney disease. Unlike Klotho, FGF23 fibroblast growth factor increases in the early stages of CKD and serves as a predictor of an unfavorable clinical outcome. Klotho and FGF23 protein levels are early, sensitive and specific diagnostic biomarkers in CKD and are of diagnostic value for predicting complications of kidney disease.


chronic kidney disease; α-Klotho protein; FGF23 fibroblast growth factor; ELISA


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