Protein Klotho and FGF23 fibroblasts growth factor as markers of chronic renal disease
Chronic kidney disease (CKD) is a global public health problem in the world. Research scientists are aimed at finding new biomarkers for CKD. Such biomarkers are α-Klotho soluble protein and fibroblast growth factor (FGF23). It was shown that the expression of Klotho protein decreases progressively as the progression of CKD and reaches low or undetectable values at the terminal stage of kidney disease. Unlike Klotho, FGF23 fibroblast growth factor increases in the early stages of CKD and serves as a predictor of an unfavorable clinical outcome. Klotho and FGF23 protein levels are early, sensitive and specific diagnostic biomarkers in CKD and are of diagnostic value for predicting complications of kidney disease.
Full Text:PDF (Русский)
Levey AS, Atkins R, Coresh J, et al. Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int. 2007;72:247-59. doi:10.1038/sj.ki.5002343.
Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011 Dec;80(12):1258-70. doi: 10.1038/ki.2011.368.
Forster RE, Jurutka PW, Hsieh JC, et al. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem Biophys Res Commun. 2011 Oct 28;414(3):557-62. doi: 10.1016/j.bbrc.2011.09.117.
Kuro-o M. Endocrine FGFs and Klothos. Austin, TX/New York: Landes Biosci./Springer. 2012. 233 pp.
Goetz R, Beenken A, Ibrahimi OA, et al. Molecular insights into the klotho depen-dent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007;27:3417-28. doi: 10.1128/MCB.02249-06.
Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004;113(4):561-8. doi: 10.1172/JCI19081.
Memon F, El-Abbadi M, Nakatani T. Does Fgf23- klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int. 2008 Sep;74(5):566-70. doi: 10.1038/ki.2008.218.
Shimamura Y, Hamada K, Inoue K, et al. Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol. 2012 Oct;16(5):722-9. doi: 10.1007/s10157-012-0621-7.
Copyright (c) 2017 KIDNEYS
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2018