Hyperuricemia — an independent factor for the progression of chronic kidney disease

M.D. Tronko, M.N. Dolzhenko, S.V. Kushnirenko, V.L. Orlenko, S.V. Potashev, O.O. Shevchuk


Objective of the research — to evaluate the efficacy of combined hypouricemic therapy in patients with hyperuricemia, urate nephropathy on the background of concomitant pathology (type 2 diabetes mellitus, hypertension) based on the dynamics of uricemia, uricosuria, the functional state of the kidneys, minimizing and eliminating the risk factors for the progression of chronic kidney disease. Sixty seven patients were involved in the study. Correction of hyperuricemia in patients with urate nephropathy and concomitant pathology (type 2 diabetes mellitus, hypertension) using phytodiuretic agent Urolesan® in combination treatment leads to normalization of metabolic processes, improvement of glomerular filtration rate, and a decrease in the level of albumin excretion.


hyperuricemia; chronic kidney disease; Urolesan®


Ivanov DD, Korzh OM. Nefrologіja v prakticі sіmejnogo lіkarja [Nephrology in Practice of Family Physician]. Donetsk: Publisher Zaslzvskyi; 2014. 464 p.

Іvanov DD, Vozіanov SO, Kushnіrenko SV, et al. Metodichnі rekomendacії. Sechokam'jana hvoroba, dismetabolіchna nefropatіja, kristalurіja. [Guidelines. Urolithiasis, dysmetabolic nephropathy, crystalluria]. Kyiv; 2014. 36 p.

Bhole V, de Vera M, Rahman MM, et al. Epidemiology of gout in women: Fifty-two-year follow up of a prospective cohort. Arthritis Rheum. 2010;62(4):1069-76. doi: 10.1002/art.27338.

Bobulescu IA, Moe OW. Renal Transport of Uric Acid: Evolving Concepts and Uncertainties. Adv Chronic Kidney Dis. 2012;19(6):358-71. PMID: 23089270. doi: 10.1053/j.ackd.2012.07.009.

Bose B, Badve SV, Hiremath SS, Boudville N, Brown FG, Cass A, et al. Effects of uric acid — lowering therapy on renal outcomes: a systematic review and meta-analysis. Nephrol Dial Transplant. 2014;29:406-13. doi: 10.1093/ndt/gft378.

Gaffo AL, Roseman JM, Jacobs DR Jr, et al. Serum urate and its relationship with alcoholic beverage intake in men and women: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Ann Rheum Dis. 2010 Nov;69(11):1965-70. doi: 10.1136%2Fard.2010.129429.

Giordano C, Karasik O, King-Morris K, Asmar A. Uric Acid as a Marker of Kidney Disease: Review of the Current Literature. Hindawi Publishing Corporation Disease Markers. 2015; 2015. doi: 10.1155/2015/382918.

Jalal DI, Chonchol M, Chen W, Targher G. Uric Acid as a Target of Therapy in CKD. Am J Kidney Dis. 2013;61(1):134-46. doi: 10.1053/j.ajkd.2012.07.021.

Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 2013 Sep;28(9):2221-8. doi: 10.1093/ndt/gft029.

Kim IY, Lee DW, Lee SB, Kwak IS. The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship. BioMed Research International. 2014;2014. doi: 10.1155/2014/638732.

KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney international supplements. 2013;3(1):73.

Krishnan E, Pandya BJ, Chung L, Dabbous O. Hyperuricemia and the risk for subclinical coronary atherosclerosis — data from a prospective observational cohort study. Arthritis Res Ther. 2011 Apr 18;13(2):66. PMID: 21501486. doi: 10.1186/ar3322.

Lottmann K, Chen X, Schadlich PK. Association between gout and all-cause as well as cardiovascular mortality: a systematic review. Curr Rheumatol Rep. 2012 Apr;14(2):195-203. PMID: 22350606. doi: 10.1007/s11926-011-0234-2.

Nacak H, van Diepen M, Qureshi AR, Carrero JJ, Stijnen T, Dekker FW, Evans M. Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease. Nephrol Dial Transplant. 2015;30(12):2039-45. PMID: 26185050. doi: 10/1093/ndt/gfv225.

Prasad OS.. Yu Xue Qing Sah Associations between Hyperuricemia and Chronic Kidney Disease: A Review. Nephro Urol Mon. 2015 May;7(3):e272-33. doi: 10.5812/numonthly.

Rodenbach KE, Schneider MF, Furth SL, Moxey-Mims MM, Mitsnefes MM, Weaver DJ, Warady BA, Schwartz GJ. Hyperuricemia and Progression of CKD in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort Study. Am J Kidney Dis. 2015 Dec;66(6):984-92. doi: 10.1053/j.ajkd.2015.06.015.

Roughley MJ, Belcher J, Mallen CD, Roddy E. Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Res Ther. 2015 Apr 1;17:90. doi: 10.1186/s13075-015-0610-9.

Ryu ES, Kim MJ, Shin HS, et al. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. The American Journal of Physiology. Renal Physiology. 2013;304(5):471-80. doi: 10.1152/ajprenal.00560.2012.

Tadashi Toyama, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, et al. Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. PLoS One. 2015;10(9):e0137449. doi: 10.1371/journal.pone.0137449.

Wang W, Bhole VM, Krishnan E. Chronic kidney disease as a risk factor for incident gout among men and women: retrospective cohort study using data from the Framingham Heart Study. BMJ Open. 2015 Apr 13;5(4):e006843. doi: 10.1136/bmjopen-2014-006843.

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